|Application ||WB, E|
|Other Accession||NP_055181.3, NP_996561.1|
|Calculated MW||61993 Da|
|Other Names||GNL3; guanine nucleotide binding protein-like 3 (nucleolar); C77032; E2IG3; NNP47; NS; E2-induced gene 3 protein; estradiol-induced nucleotide binding protein; guanine nucleotide-binding protein-like 3; novel nucleolar protein 47; nucleolar GTP-binding protein 3; nucleostemin|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-TENKAKSGKQNS, from the internal region of the protein sequence according to NP_055181.3; NP_996561.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GNL3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus|
|Tissue Location||Increased levels in lung tissue in cancer patients.|
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Nucleostemin affects the proliferation but not differentiation of oral squamous cell carcinoma cells. Yoshida R, Fujimoto T, Kudoh S, Nagata M, Nakayama H, Shinohara M, Ito T. Cancer science 2011 Jul 102 (7): 1418-23.
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