|Application ||WB, E|
|Other Accession||315609(rat), NP_000724.1|
|Predicted||Human, Rat, Pig|
|Calculated MW||23147 Da|
|Other Names||CD3E; CD3e molecule, epsilon (CD3-TCR complex); IMD18; T3E; TCRE; CD3-epsilon; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-RKGQRDLYSGLNQR, from the internal region of the protein sequence according to NP_000724.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD3E Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW. The Journal of experimental medicine 2012 Dec 209 (13): 2423-39.
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