|Application ||WB, E|
|Other Accession||NP_001164645.1, NP_001328.1|
|Calculated MW||40396 Da|
|Other Names||CX3CR1; chemokine (C-X3-C motif) receptor 1; CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; CX3C chemokine receptor 1; G protein-coupled receptor 13; G-protein coupled receptor 13; beta chemokine receptor-like 1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-DQFPESVTENFEYD, from the internal region (near N terminus) of the protein sequence according to NP_001164645.1; NP_001328.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CX3CR1 Antibody (internal region (near N terminus)) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in lymphoid and neural tissues.|
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The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P, Laghi L, Malesci A, Cervo L, Malosio M, Reni M, Zerbi A, Di Carlo V, Mantovani A, Allavena P. Cancer research 2008 Nov 68 (21): 9060-9.
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