|Application ||WB, E|
|Other Accession||219158(mouse), 306007(rat), NP_066997.3|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||102902 Da|
|Other Names||CCAR2; cell cycle and apoptosis regulator 2; DBC-1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC; cell cycle and apoptosis regulator protein 2; cell division cycle and apoptosis regulator protein 2; deleted in breast cancer 1; p30 DBC protein|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-ESHNRFSATEVTNK, from the internal region of the protein sequence according to NP_066997.3.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CCAR2 / DBC1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.|
|Cellular Location||Nucleus. Note=Recruited to chromatin, post-UV irradiation|
|Tissue Location||Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The overexpression of DBC1 in esophageal squamous cell carcinoma correlates with poor prognosis. Kim SH, Kim JH, Yu EJ, Lee KW, Park CK. Histology and histopathology 2012 Jan 27 (1): 49-58.
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