|Application ||WB, E|
|Other Accession||219158(mouse), 306007(rat), NP_066997.3|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||102902 Da|
|Other Names||CCAR2; cell cycle and apoptosis regulator 2; DBC-1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC; cell cycle and apoptosis regulator protein 2; cell division cycle and apoptosis regulator protein 2; deleted in breast cancer 1; p30 DBC protein|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-ESHNRFSATEVTNK, from the internal region of the protein sequence according to NP_066997.3.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CCAR2 / DBC1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.|
|Cellular Location||Nucleus. Note=Recruited to chromatin, post-UV irradiation|
|Tissue Location||Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.|
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The overexpression of DBC1 in esophageal squamous cell carcinoma correlates with poor prognosis. Kim SH, Kim JH, Yu EJ, Lee KW, Park CK. Histology and histopathology 2012 Jan 27 (1): 49-58.
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