|Application ||WB, E|
|Other Accession||327826(mouse), NP_006645.3|
|Predicted||Human, Mouse, Pig, Cow, Dog|
|Calculated MW||57029 Da|
|Other Names||FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-SRDEDDNLGPKTPS, from the internal region of the protein sequence according to NP_006645.3.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FRS2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.|
|Cellular Location||Endomembrane system. Note=Cytoplasmic, membrane-bound|
|Tissue Location||Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis|
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High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma. Wang X, Asmann YW, Erickson-Johnson MR, Oliveira JL, Zhang H, Moura RD, Lazar AJ, Lev D, Bill K, Lloyd RV, Yaszemski MJ, Maran A, Oliveira AM. Genes, chromosomes & cancer 2011 Nov 50 (11): 849-58.
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