|Application ||WB, E|
|Calculated MW||130848 Da|
|Other Names||ITGA1; integrin, alpha 1; CD49a; VLA1; CD49 antigen-like family member A; VLA-1; integrin alpha-1; laminin and collagen receptor; very late activation protein 1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-DKHDFQDSVRIT, from the internal region of the protein sequence according to NP_852478.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ITGA1 / VLA1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen. Roberts AI, Brolin RE, Ebert EC. Immunology 1999 Aug 97 (4): 679-85.
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