|Application ||WB, E|
|Other Accession||NP_065434.1, NP_001158162.1, NP_001158163.1|
|Calculated MW||62750 Da|
|Other Names||AMHR2; anti-Mullerian hormone receptor, type II; AMHR; MISR2; MISRII; MRII; AMH type II receptor; MIS type II receptor; Muellerian inhibiting substance type II receptor; Mullerian inhibiting substance type II receptor; anti-Muellerian hormone type II receptor|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence ESLHCDPSPRAH, from the internal region of the protein sequence according to NP_065434.1; NP_001158162.1; NP_001158163.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-AMHR2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Mutant isoforms of the anti-Müllerian hormone type II receptor are not expressed at the cell membrane. Faure E, Gouédard L, Imbeaud S, Cate R, Picard JY, Josso N, di Clemente N. The Journal of biological chemistry 1996 Nov 271 (48): 30571-5.
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