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Goat Anti-ASIC1 Antibody (C Terminus)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-ASIC1 Antibody (C Terminus) AF4209a
    AF4209a (0.3 µg/ml) staining of Mouse fetal Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78348
Other Accession 11419(mouse), 79123(rat), NP_064423.2, NP_001086.2, NP_001243759.1
Reactivity Mouse
Predicted Human, Mouse, Rat, Pig, Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 59909 Da
Additional Information
Gene ID 41
Other Names ASIC1; acid-sensing (proton-gated) ion channel 1; ACCN2; ASIC; BNaC2; Cation channel, amiloride-sensitive, neuronal, 2; acid-sensing ion channel 1; acid-sensing ion channel 1a protein; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-NILPHHPARGT, from the C Terminus of the protein sequence according to NP_064423.2; NP_001086.2; NP_001243759.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ASIC1 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASIC1
Synonyms ACCN2, BNAC2
Function Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Cellular Location Cell membrane; Multi- pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons Colocalizes with DLG4 (By similarity).
Tissue Location Expressed in most or all neurons.
Research Areas
Citations (0)

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Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. Hoagland EN, Sherwood TW, Lee KG, Walker CJ, Askwith CC. The Journal of biological chemistry 2010 Dec 285 (53): 41852-62.

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$ 325.00
Cat# AF4209a
(40 western blots)
Availability: 7-10 days
Bulk Size
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