|Application ||WB, E|
|Other Accession||11419(mouse), 79123(rat), NP_064423.2, NP_001086.2, NP_001243759.1|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||59909 Da|
|Other Names||ASIC1; acid-sensing (proton-gated) ion channel 1; ACCN2; ASIC; BNaC2; Cation channel, amiloride-sensitive, neuronal, 2; acid-sensing ion channel 1; acid-sensing ion channel 1a protein; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-NILPHHPARGT, from the C Terminus of the protein sequence according to NP_064423.2; NP_001086.2; NP_001243759.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ASIC1 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.|
|Cellular Location||Cell membrane; Multi- pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons Colocalizes with DLG4 (By similarity).|
|Tissue Location||Expressed in most or all neurons.|
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Provided below are standard protocols that you may find useful for product applications.
Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. Hoagland EN, Sherwood TW, Lee KG, Walker CJ, Askwith CC. The Journal of biological chemistry 2010 Dec 285 (53): 41852-62.
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