|Application ||WB, E|
|Other Accession||12153(mouse), 83470(rat), NP_001190.1, NP_006120.1|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||111249 Da|
|Other Names||BMP1; bone morphogenetic protein 1; OI13; PCOLC; PCP; PCP2; TLD; mammalian tolloid protein; procollagen C-endopeptidase; procollagen C-proteinase|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-DTIVPKYEVNGVK, from the internal region of the protein sequence according to NP_001190.1; NP_006120.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BMP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co- localizes with POSTN in the Golgi.|
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Provided below are standard protocols that you may find useful for product applications.
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains. Wermter C, Höwel M, Hintze V, Bombosch B, Aufenvenne K, Yiallouros I, Stöcker W. Biological chemistry 2007 May 388 (5): 513-21.
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