|Application ||WB, E|
|Calculated MW||53900 Da|
|Other Names||BPI; bactericidal/permeability-increasing protein; BPIFD1; rBPI; BPI fold containing family D, member 1; CAP 57; bactericidal permeability-increasing protein; recombinant BPI holoprotein, rBPI|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-KIPDYSDSFKIKH, from the internal region of the protein sequence according to NP_001716.2.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BPI Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.|
|Cellular Location||Secreted. Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.|
|Tissue Location||Restricted to cells of the myeloid series.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A novel role for the bactericidal/permeability increasing protein in interactions of gram-negative bacterial outer membrane blebs with dendritic cells. Schultz H, Hume J, Zhang de S, Gioannini TL, Weiss JP. Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 179 (4): 2477-84.
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