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Goat Anti-AIFM1 Antibody (C Terminus)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-AIFM1 Antibody (C Terminus) AF4215a
    AF4215a (0.01 µg/ml) staining of Jurkat lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95831
Other Accession 26926(mouse), 83533(rat), NP_004199.1, NP_665811.1, NP_665812.1, NP_001124318.1
Reactivity Human
Predicted Human, Mouse, Rat, Pig, Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 66901 Da
Additional Information
Gene ID 9131
Other Names AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; AIF; CMTX4; COWCK; COXPD6; PDCD8; apoptosis-inducing factor 1, mitochondrial; programmed cell death 8 (apoptosis-inducing factor); striatal apoptosis-inducing factor
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-NEVAKLFNIHED, from the C Terminus of the protein sequence according to NP_004199.1; NP_665811.1; NP_665812.1; NP_001124318.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-AIFM1 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIFM1
Synonyms AIF, PDCD8
Function Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Cellular Location Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region Isoform 5: Cytoplasm
Tissue Location Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.
Research Areas
Citations (0)

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The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. Lewis EM, Wilkinson AS, Jackson JS, Mehra R, Varambally S, Chinnaiyan AM, Wilkinson JC. The Journal of biological chemistry 2012 Dec 287 (52): 43862-75.

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$ 325.00
Cat# AF4215a
(40 western blots)
Availability: 7-10 days
Bulk Size
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