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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Goat Anti-SYVN1 Antibody (internal region)   

Goat Anti-SYVN1 Antibody (internal region)

Purified Goat Polyclonal Antibody

  • IHC-P - Goat Anti-SYVN1 Antibody (internal region) AF4216a
    AF4216a (2 µg/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86TM6
Other Accession 361712(rat), NP_115807.1, NP_757385.1
Reactivity Human
Predicted Human, Rat
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 67685 Da
Additional Information
Gene ID 84447
Other Names SYVN1; synovial apoptosis inhibitor 1, synoviolin; HRD1; KIAA1810; MGC40372; synoviolin 1
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-RALEGHERQHLE, from the internal region of the protein sequence according to NP_115807.1; NP_757385.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SYVN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYVN1
Synonyms HRD1, KIAA1810
Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein
Tissue Location Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).
Research Areas
Citations (0)

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[Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases] Kaneko M, Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2009 May 133 (5): 252-6.

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$ 325.00
Cat# AF4216a
(40 western blots)
Availability: 7-10 days
Bulk Size
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