|Application ||WB, E|
|Calculated MW||55542 Da|
|Other Names||FCRL2; Fc receptor-like 2; CD307b; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A; SPAP1B; SPAP1C; Fc receptor-like protein 2; IFGP family protein 4; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1; fc receptor h|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-DKTSNIVKIKVQE, from the internal region of the protein sequence according to NP_110391.2.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FCRL2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FCRH2, IFGP4, IRTA4, SPAP1|
|Function||May have an regulatory role in normal and neoplastic B cell development.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. Jackson TA, Haga CL, Ehrhardt GR, Davis RS, Cooper MD. Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 185 (12): 7405-12.
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