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Goat Anti-PLA2G2A Antibody (internal region)

Purified Goat Polyclonal Antibody

     
  • WB - Goat Anti-PLA2G2A Antibody (internal region) AF4225a
    AF4225a (0.1 µg/ml) staining of Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P14555
Other Accession NP_000291.1
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 16083 Da
Additional Information
Gene ID 5320
Other Names PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2; GIIC sPLA2; NPS-PLA2; group IIA phospholipase A2; non-pancreatic secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; phospholi
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-SYKFSNSGSRIT, from the internal region of the protein sequence according to NP_000291.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PLA2G2A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA2G2A
Synonyms PLA2B, PLA2L, RASF-A
Function Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
Cellular Location Cell membrane; Peripheral membrane protein. Secreted
Research Areas
Citations (0)

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References

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells. Villanueva EB, Little JP, Lambeau G, Klegeris A. Molecular and cellular neurosciences 2012 Apr 49 (4): 430-8.

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$ 335.00
Cat# AF4225a
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