|Application ||WB, E|
|Calculated MW||35213 Da|
|Other Names||LYVE1; lymphatic vessel endothelial hyaluronan receptor 1; CRSBP-1; HAR; LYVE-1; XLKD1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; hyaluronic acid receptor; lymphatic vessel endothelial hyaluronic acid receptor 1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-STETEPFVENK, from the internal region of the protein sequence according to NP_006682.2.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-LYVE1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CRSBP1, HAR, XLKD1|
|Function||Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.|
|Cellular Location||Membrane; Single-pass type I membrane protein Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface|
|Tissue Location||Mainly expressed in endothelial cells lining lymphatic vessels.|
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The interaction between LYVE-1 with hyaluronan on the cell surface may play a role in the diversity of adhesion to cancer cells. Du Y, Liu H, He Y, Liu Y, Yang C, Zhou M, Wang W, Cui L, Hu J, Gao F. PloS one 2013 8 (5): e63463.
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