|Application ||WB, E|
|Calculated MW||56278 Da|
|Other Names||CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450; 1, 4-cineole 2-exo-monooxygenase; cytochrome P450 2B6; cytochrome P450 IIB1; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-HSVEKHRETLDPS, from the internal region of the protein sequence according to NP_000758.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CYP2B6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Expressed in liver, lung and heart right ventricle.|
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Provided below are standard protocols that you may find useful for product applications.
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy. Dickmann LJ, Isoherranen N. Drug metabolism and disposition: the biological fate of chemicals 2013 Feb 41 (2): 270-4.
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