|Application ||WB, E|
|Other Accession||NP_066978.1, NP_001138368.1, NP_001138369.1, NP_001138365.1, NP_001138366.1, NP_001138367.1, NP_001138371.1|
|Calculated MW||45775 Da|
|Other Names||CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209 antigen; HIV gpl20-binding protein; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-spe|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-NRGEPNNVGEED, from the internal region of the protein sequence according to NP_066978.1; NP_001138368.1; NP_001138369.1; NP_001138365.1; NP_001138366.1; NP_001138367.1; NP_001138371.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DC-SIGN / CD209 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 3: Cell membrane; Single-pass type II membrane protein Isoform 5: Cell membrane; Single-pass type II membrane protein Isoform 7: Secreted. Isoform 9: Secreted. Isoform 11: Secreted.|
|Tissue Location||Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes|
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Provided below are standard protocols that you may find useful for product applications.
Role of DC-SIGN in Lassa virus entry into human dendritic cells. Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S. Journal of virology 2013 Nov 87 (21): 11504-15.
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