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Goat Anti-DC-SIGN / CD209 Antibody (internal region)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-DC-SIGN / CD209 Antibody (internal region) AF4236a
    AF4236a (0.3 µg/ml) staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NNX6
Other Accession NP_066978.1, NP_001138368.1, NP_001138369.1, NP_001138365.1, NP_001138366.1, NP_001138367.1, NP_001138371.1
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 45775 Da
Additional Information
Gene ID 30835
Other Names CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209 antigen; HIV gpl20-binding protein; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-spe
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-NRGEPNNVGEED, from the internal region of the protein sequence according to NP_066978.1; NP_001138368.1; NP_001138369.1; NP_001138365.1; NP_001138366.1; NP_001138367.1; NP_001138371.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DC-SIGN / CD209 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD209
Synonyms CLEC4L
Function Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
Cellular Location Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 3: Cell membrane; Single-pass type II membrane protein Isoform 5: Cell membrane; Single-pass type II membrane protein Isoform 7: Secreted. Isoform 9: Secreted. Isoform 11: Secreted.
Tissue Location Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes
Research Areas
Citations (0)

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Role of DC-SIGN in Lassa virus entry into human dendritic cells. Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S. Journal of virology 2013 Nov 87 (21): 11504-15.

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$ 325.00
Cat# AF4236a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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