|Application ||WB, E|
|Other Accession||NP_000751.1, NP_724781.1, NP_758519.1|
|Calculated MW||92156 Da|
|Other Names||CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; GCSFR; CD114 antigen; G-CSF receptor; G-CSF-R; OTTHUMP00000009703; OTTHUMP00000009704; OTTHUMP00000009705; granulocyte colony-stimulating factor receptor|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-PPELGKSPLTHYT, from the internal region of the protein sequence according to NP_000751.1; NP_724781.1; NP_758519.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-G-CSF receptor / CSF3R Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.|
|Cellular Location||Isoform 2: Secreted.|
|Tissue Location||One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta|
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Provided below are standard protocols that you may find useful for product applications.
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor. Meenhuis A, Verwijmeren C, Roovers O, Touw IP. Biochem J. 2011 Mar 1;434(2):343-51.
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