|Application ||WB, E|
|Other Accession||NP_001970.2, NP_001243411.1, NP_001243412.1|
|Calculated MW||62616 Da|
|Other Names||EPHX2; epoxide hydrolase 2, cytoplasmic; CEH; SEH; bifunctional epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-SRTFKSLFRASDES, from the internal region of the protein sequence according to NP_001970.2; NP_001243411.1; NP_001243412.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-EPHX2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.|
|Cellular Location||Cytoplasm. Peroxisome.|
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Provided below are standard protocols that you may find useful for product applications.
Soluble epoxide hydrolase dimerization is required for hydrolase activity. Nelson JW, Subrahmanyan RM, Summers SA, Xiao X, Alkayed NJ. The Journal of biological chemistry 2013 Mar 288 (11): 7697-703.
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