|Application ||WB, E|
|Other Accession||NP_001020419.1, NP_001939.1, NP_001020420.1|
|Predicted||Human, Pig, Cow|
|Calculated MW||26563 Da|
|Other Names||DUT; deoxyuridine triphosphatase; dUTPase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-QLRFARLSEHATAPT, from the internal region of the protein sequence according to NP_001020419.1; NP_001939.1; NP_001020420.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-dUTPase / DUT Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.|
|Cellular Location||Isoform 2: Nucleus.|
|Tissue Location||Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG. The Journal of biological chemistry 2007 Nov 282 (46): 33572-82.
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