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Goat Anti-dUTPase / DUT Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P33316 |
| Other Accession | NP_001020419.1, NP_001939.1, NP_001020420.1 |
| Reactivity | Human |
| Predicted | Human, Pig, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 26563 Da |
| Gene ID | 1854 |
|---|---|
| Other Names | DUT; deoxyuridine triphosphatase; dUTPase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-QLRFARLSEHATAPT, from the internal region of the protein sequence according to NP_001020419.1; NP_001939.1; NP_001020420.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-dUTPase / DUT Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUT |
|---|---|
| Function | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator- activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). |
| Cellular Location | [Isoform 2]: Nucleus |
| Tissue Location | Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG. The Journal of biological chemistry 2007 Nov 282 (46): 33572-82.
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$ 341.00
Cat# AF4249a
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