|Application ||WB, E|
|Calculated MW||51329 Da|
|Other Names||GPR39; G protein-coupled receptor 39; G-protein coupled receptor 39|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-HAHSTTDSARFVQRP, from the internal region of the protein sequence according to NP_001499.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GPR39 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many tissues, including the stomach, intestine and hypothalamus.|
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Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. Xie F, Liu H, Zhu YH, Qin YR, Dai Y, Zeng T, Chen L, Nie C, Tang H, Li Y, Fu L, Guan XY. BMC cancer 2011 11 : 86.
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