|Application ||WB, E|
|Calculated MW||34516 Da|
|Other Names||HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; EDH17B3; SDR12C2; 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; short chain dehydrogenase/reductase family 12C, member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testo|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-SHFLNAPDEIQSLIH, from the internal region of the protein sequence according to NP_000188.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-HSD17B3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.|
|Cellular Location||Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
The microsomal enzyme 17β-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase. Legeza B, Balázs Z, Nashev LG, Odermatt A. Endocrinology 2013 Jan 154 (1): 205-13.
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