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Goat Anti-HSD17B3 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P37058 |
| Other Accession | NP_000188.1 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 34516 Da |
| Gene ID | 3293 |
|---|---|
| Other Names | HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; EDH17B3; SDR12C2; 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; short chain dehydrogenase/reductase family 12C, member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testo |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-SHFLNAPDEIQSLIH, from the internal region of the protein sequence according to NP_000188.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-HSD17B3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSD17B3 (HGNC:5212) |
|---|---|
| Synonyms | EDH17B3, SDR12C2 |
| Function | Catalyzes the conversion of 17-oxosteroids to 17beta- hydroxysteroids (PubMed:8075637, PubMed:16216911, PubMed:27927697, PubMed:26545797). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697, PubMed:26545797). Testosterone is the key androgen driving male development and function (PubMed:8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911). Can reduce 11-ketoandrostenedione as well as 11beta- hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697). |
| Cellular Location | Endoplasmic reticulum |
| Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
References
The microsomal enzyme 17β-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase. Legeza B, Balázs Z, Nashev LG, Odermatt A. Endocrinology 2013 Jan 154 (1): 205-13.
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