Goat Anti-CNGB3 (aa175-186) Antibody
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9NQW8 |
Other Accession | NP_061971.3, 54714 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 92167 Da |
Gene ID | 54714 |
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Other Names | CNGB3; cyclic nucleotide gated channel beta 3; ACHM1; CNG channel beta-3; cone photoreceptor cGMP-gated cation channel beta-subunit; cyclic nucleotide-gated cation channel beta-3; cyclic nucleotide-gated cation channel modulatory subunit |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | Peptide with sequence C-ESDDKPTEHYYR, from the internal region of the protein sequence according to NP_061971.3. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-CNGB3 (aa175-186) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNGB3 |
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Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Tissue Location | Expressed specifically in the retina. |
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Provided below are standard protocols that you may find useful for product applications.
References
Peng C, Rich ED, Varnum MD.
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