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Goat Anti-ASCL1 (aa79-91) Antibody

Purified Goat Polyclonal Antibody

     
  • WB - Goat Anti-ASCL1 (aa79-91) Antibody AF4317a
    AF4317a (1 µg/ml) staining of Mouse (A) and Rat (B) Lung lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P50553
Other Accession NP_004307.2, 429, 17172 (mouse), 64186 (rat)
Reactivity Mouse, Rat
Predicted Human, Cow
Host Goat
Clonality Polyclonal
Calculated MW 25454 Da
Additional Information
Gene ID 429
Other Names ASCL1; achaete-scute complex homolog 1 (Drosophila); ASH1; HASH1; MASH1; bHLHa46; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute homolog 1; class A basic helix-loop-helix protein 46
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-HKSAPKQVKRQRS, from the internal region of the protein sequence according to NP_004307.2.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ASCL1 (aa79-91) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASCL1 (HGNC:738)
Function Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q02067}.
Research Areas
Citations (0)

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References

Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H.

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$ 335.00
Cat# AF4317a
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