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Somatostatin Receptor Type 5 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Somatostatin Receptor Type 5 (extracellular) Antibody AG1017-050
    Western blot analysis of rat brain lysates: 1. Anti-Somatostatin Receptor Type 5 (extracellular) antibody (#AG1017), (1:200).
    2. Anti-Somatostatin Receptor Type 5 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Somatostatin Receptor Type 5 (extracellular) Antibody AG1017-050
    Expression of SSTR5 in mouse cerebellum Immunohistochemical staining of Somatostatin receptor 5 (SST5R) in mouse cerebellum using Anti-Somatostatin Receptor Type 5 (extracellular) antibody (#AG1017). A. SST5R (red) appears in Purkinje cells (horizontal arrows) and in molecular layer interneurons (vertical arrows). B. Parvalbumin (green) appears in the Purkinje cells and their processes. C. merge of SST5R and parvalbumin demonstrates co-localization in Purkinje cells (horizontal arrows) but not in the molecular layer (vertical cells). DAPI is used as the counterstain (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30938
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 39971 Da
Homology Mouse - identical; human - 12/14 amino acid residues identical.
Additional Information
Gene ID 25354
Other Names Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R, Sstr5
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CEPLSLASTPSWNAS, corresponding to amino acid residues 2-15 of rat somatostatin receptor type 5 (accession P30938). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28, that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility. SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation. In contrast to SSTR1-4 that bind SST-14 and SST-28 with similar affinity, SSTR5 has a much greater affinity to SST-28 over SST-14. SSTRs are widely expressed in both brain and peripheral tissues but with receptor subtype variations between the different cell types. Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain. SSTR5 is expressed in a variety of tissues and cells, including pancreas, colonic mucosa, small intestine, heart, and vascular smooth muscle cells. SSTR5 has been shown to mediate growth inhibition and cell proliferation, and to play an important role in cancer growth regulation as one of the most potent inhibitory receptors. Abgent is pleased to offer a highly specific antibody directed against the N-terminus domain of the rat SSTR5.  Anti-Somatostatin Receptor Type 5 (extracellular) antibody (#AG1017), can be used in Western blot analysis and immunohistochemical applications, and recognizes SSTR1 in mouse and rat samples.


References 1. Patel, Y.C. (1999) Front Neuroendocrin. 20,157. 2. Weckbecker, G. et al. (2003) Nat. Rev. Drug Discov. 2, 999. 3. Culler, M.D. et al. (2002) Ann. Endocrinol. (Paris) 63, 2S5. 4. Corleto, V.D. et al. (2004) Dig. Liver Dis. 36, S8. 5. 6. Yang, S-K. et al. (2007) Am J Physiol Endocrinol Metab. In press.

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$ 475.00
$ 575.00
Cat# AG1017-050
(40 western blots)
Availability: 2-3 weeks
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