|Calculated MW||42746 Da|
|Homology||Mouse - identical; human - 13/15 amino acid residues identical.|
|Other Names||Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2, Sstr1|
|Related products for control experiments||Control peptide antigen (supplied with the antibody free of charge).|
|Target/Specificity||Peptide CSRGPGSGAADGMEE, corresponding to amino acid residues 26-40 of rat somatostatin receptor type 1 (Accession# P28646). Extracellular, N-terminus.|
|Peptide Confirmation||Confirmed by amino acid analysis and massspectrography.|
|Format||Affinity purified antibody, lyophilized powder|
|Reconstitution||50 µl or 0.2 ml deionized water, depending on the sample size.|
|Antibody Concentration After Reconstitution||0.8 mg/ml.|
|Buffer After Reconstitution||Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.|
|Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Storage After Reconstitution||The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).|
|Control Antigen Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Control Antigen Reconstitution||100 µl water.|
|Control Antigen Storage After Reconstitution||-20ºC.|
|Preadsorption Control||1 µg peptide per 1 µg antibody.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both stimulatory and inhibitory manner.1, 2 Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.2 Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.4 Abgent is pleased to offer a highly specific antibody directed against the N-terminus domain of the rat SSTR1. Anti-Somatostatin Receptor Type 1 antibody (#AG1021), can be used in western blot analysis, and recognizes SSTR1 in rat samples.
1. Hofland, LJ. and Lamberts, S.W.J. (2001) Annals of Oncology 12, S31.
2. Fombonne, J. et al. (2003) Rep. Biol. Endocrinol. 1, 19.
3. Slooter, G.D. et al. (2001) Br. J. Surg. 88, 31.
4. Schulz, S. et al. (2002) Gynecologic Oncology 84, 235.
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