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>   home   >   Products   >   Primary Antibodies   >   NaVBeta4 (extracellular) Antibody   

NaVBeta4 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - NaVBeta4 (extracellular) Antibody AG1022-050
    Western blot analysis of  rat brain (lanes 1 and 5), rat cortex (lane 2 and 6), mouse brain (lanes 3 and 7) and SH-SY5Y (lanes 4 and 8) lysates: 1-4. Anti-Navβ4 (extracellular) antibody (#AG1022), (1:800).
    5-8. Anti-Navβ4 (extracellular) antibody preincubated with the control peptide antigen.
  • ICC - NaVBeta4 (extracellular) Antibody AG1022-050
    Expression of NaVβ4 in rat Pheochromocytoma (PC12) cells Immunocytochemical staining of intact living rat Pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-Navβ4 (extracellular) antibody (#AG1022), (1:50) followed by goat anti-rabbit-AlexaFluor-594 secondary antibody (red). B. Extracellular staining merged with live view of the cells.
  • IHC - NaVBeta4 (extracellular) Antibody AG1022-050
    Expression of NaVβ4 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti-NaVβ4 (extracellular) antibody (#AG1022) followed by goat anti-rabbit-AlexaFluor-594 secondary antibody. A. NaVβ4 labeling (red) appears in the cell bodies of the DRG neurons. B. Nuclear staining using DAPI as the counterstain (blue). C. Merged image of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7M730
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 25247 Da
Homology Mouse - identical; human - 11/14 amino acid residues identical.
Additional Information
Gene ID 315611
Other Names Sodium channel subunit beta-4, Scn4b
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85-98 of rat NaV־²4 (Accession Q7M730). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.85 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Resuspended antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named Nav1.1-Nav1.94,5.  The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9) 2,3. Mammalian Na+ channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit6,7.   Navβ4 has been associated with Long QT syndrome8 and with Huntington's disease, showing a distinct down regulation of NaVβ4 in the presymptomatic stage of HD mice, whereas other voltage-gated ion channel subunits were later decreased9.


References 1. Wu, L. et al. (2002) NeuroReport 13, 2547. 2. Fang, X. et al. (2002) J. Neurosci. 22, 7425. 3. Fjell, J. et al. (2000) NeuroReport 11, 199. 4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 5. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291. 6. Isom, L.L. (2001) Neuroscientist 7, 42. 7. Catterall, W.A. et al. (2003) Pharmacol. Rev.  55, 575. 8. Medeiros-Domingo, A. et al. (2007) Circulation 116, 134. 9. Oyama, F. et al. (2006) J. Neurochem. 98, 518.

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$ 475.00
$ 575.00
Cat# AG1022-050
(40 western blots)
Availability: 2-3 weeks
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