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NaV1.4 Antibody

Affinity purified polyclonal antibody

  • WB - NaV1.4 Antibody AG1025-050
    Western blot analysis of rat skeletal muscle lysate: 1. Anti-Nav1.4 antibody (#AG1025), (1:200).
    2. Anti-Nav1.4 antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15390
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 208867 Da
Homology Mouse- 15/17 amino acid residues identical; human- 14/17 amino acid residues identical.
Additional Information
Gene ID 25722
Other Names Sodium channel protein type 4 subunit alpha, Mu-1, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav14, Scn4a
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide EDKELKDNHILNHVG(C), corresponding to amino acid residues 877-891 of rat Nav1.4 (Accession P15390 ).ֲ ֲ Intracellular loop between domains II and III.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and masspectrography.
Application Details Western blot analysis (WB): - Mouse muscle lysate (see Boyer, J.G. et al. (2013) in Product Citations). - Human cardiac cells (see Baroni, D. et al. (2013) in Product Citations). Immunocytochemistry (IC): - Mouse LVA myocytes (1:100) (see Ednie, A.R. et al. (2013) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
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Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.4-5  Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6 The isoform Nav1.4, is primarily expressed in skeletal muscle.7 Different missense mutations in the gene for the Nav1.4 are correlated with several muscular diseases such as, Paramyotonia congenital (PMC), PMC without cold paralysis, potassium-aggravating myotonia, and hyperkalemic periodic paralysis.8


References 1. Wu, L. et al. (2002) NeuroReport 13, 2547. 2. Fang, X. et al. (2002) J. Neurosci. 22, 7425. 3. Fjell, J. et al. (2000) NeuroReport 11, 199. 4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 5. Lai, J. et al. (2003) Curr.Opin. Neurobiol 13, 291. 6. Isom, L.L. (2001) Neuroscientist  7, 42. 7. Catterall, W.A. et al. (2005) Pharmacological Reviews 57, 397. 8. Sasaki, R. et al. (1999) Arch. Neurol. 56, 692.

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$ 475.00
$ 575.00
Cat# AG1025-050
(40 western blots)
Availability: 2-3 weeks
Bulk Size
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