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>   home   >   Products   >   Primary Antibodies   >   NaV1.8 Antibody   

NaV1.8 Antibody

Affinity purified polyclonal antibody

  • WB - NaV1.8 Antibody AG1029-025
    Western blot analysis of rat DRG lysates:
    1. Anti-Nav1.8 antibody (#AG1029), (1:200).
    2. Anti-Nav1.8 antibody, preincubated with the control peptide antigen.
  • IHC - NaV1.8 Antibody AG1029-025
    Expression of Nav1.8 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti-Nav1.8 antibody (#AG1029). Nav1.8 staining (red) is cytoplasmic and the intensity varies among DRG cells. There is a partial overlap in the distribution of Nav1.8 and neurofilament 200 (green).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63554
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Homology Mouse - 14/15 amino acid residues identical; human - 7/15 amino acid residues identical.
Additional Information
Gene ID 29571
Other Names PN3
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)EDEVAAKEGNSPGPQ, corresponding to amino acid residues 1943-1956 of rat Nav1.8 (Accession Q63554). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Application Details Western blot analysis (WB): - Rat sciatic nerve and rat DRG (1:2000) (see Su, Y.Y. et al. (2013) in Product Citations). - Rat colon lysates (see Hu, S. et al. (2013) in Product Citations). - Rat L4-6 DRG lysates (1:200), (see Yu, Y.Q. et al. (2011) in Product Citations).   Immunohistochemistry (IH): - Rat DRG (1:1000) (see Su, Y.Y. et al. (2013) in Product Citations). - Rat L4-6 DRG sections (1:200), (see Yu, Y.Q. et al. (2011) in Product Citations). - Rat L4-6 DRG sections (1:500), (see Belkouch, M. et al. (2011) in Product Citations). - Human Neuromas (1:100) (see Black, J.A. et al. (2008) in Product Citations).   Immunocytochemistry (IC): - ND7-23 cells (1:1000) (see Su, Y.Y. et al. (2013) in Product Citations). - Rat cultured DRGs (1:500), (see Belkouch, M. et al. (2011) in Product Citations).  
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.9 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific. Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission. Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6


References 1.  Wu, L. et al. (2002) NeuroReport 13, 2547. 2. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 3. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291. 4. Fang, X. et al. (2002) J. Neurosci. 22, 7425. 5. Fjell, J. et al. (2000) NeuroReport 11, 199. 6. Renganathan, M. et al. (2003) Brain Res. 959, 235.

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1029-025
(40 western blots)
Availability: 2-3 weeks
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