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>   home   >   Products   >   Primary Antibodies   >   NaV1.7 Antibody   

NaV1.7 Antibody

Affinity purified polyclonal antibody

  • WB - NaV1.7 Antibody AG1034-025
    Western blot analysis of ND7/23 cell lysate (lanes 1,3) and rat brain membranes (lanes 2,4):
    1,2.  Anti-Nav1.7 antibody (#AG1034), (1:200).
    3,4.  Anti-Nav1.7 antibody, preincubated with the control peptide antigen.
  • WB - NaV1.7 Antibody AG1034-025
    Western blot analysis of DRG lysates: 1. Anti-NaV1.7 antibody (#AG1034), (1:200).
    2. Anti- NaV1.7 antibody, preincubated with the control peptide antigen.
  • IHC - NaV1.7 Antibody AG1034-025
    Expression of Nav1.7 in rat DRG
    Immunohistochemical staining of rat dorsal root ganglion (DRG) using Anti-Nav1.7 antibody (#AG1034 ). A. Nav1.7 channel (red) in DRG neurons. B. Staining with mouse anti-Parvalbumin (green) in the same DRG section. C. Confocal merge of Nav1.7 and Parvalbumin demonstrates colocalization (arrows).
  • ICC - NaV1.7 Antibody AG1034-025
    Expression of Nav1.7 in rat DRG primary culture Immunocytochemical staining of paraformaldehyde-fixed and permeabilized rat dorsal root ganglion (DRG) primary culture. Cells were stained using Anti-Nav1.7 antibody (#AG1034), (1:200) followed by goat anti-rabbit-AlexaFluor-488 secondary antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O08562
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 226039 Da
Homology Rabbit - 14/15 amino acid residues identical; human, mouse - 13/15 amino acid residues identical.
Additional Information
Gene ID 78956
Other Names Sodium channel protein type 9 subunit alpha, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav17, Scn9a
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)EFTSIGRSR IMGLSE, corresponding to amino acid residues 446-460 of rat Nav1.7ֲ (Accession O08562).ֲ ֲ Intracellular loop between domains I and II.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Application Details Western blot analysis (WB): - Rat colon lysate (see Wang, Y. et al. (2012) in Product Citations).   Immunohistochemistry (IH): - Human cervical tissue (1:25) (see Hernandez-Plata, E. et al. (2012) in Product Citations). - Mouse dorsal root ganglia (DRGs) (1:1000) (see Amaya, F. et al. (2006) in Product Citations).   Immunocytochemistry (IC): - Human cervical cancer cell line (1:25) (see Hernandez-Plata, E. et al. (2012) in Product Citations).  
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named NaV1.1-NaV1.9.4-5  The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7)  and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6-8   NaV1.7 is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain of function mutations in the NaV1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities).9-11 Loss, or function mutations in NaV1.7 channels, leads to complete ablation of pain perception in humans.11  These  recent findings highlight the role of this NaV isoform and the subset of DRG neurons that express this channel in physiological pain sensation.


References 1. Wu, L. et al. (2002) NeuroReport 13, 2547. 2.  Fang, X. et al. (2002) J. Neurosci. 22, 7425. 3. Fjell, J. et al. (2000) NeuroReport 11, 199. 4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 5. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291. 6. Isom, L.L. (2001) Neuroscientist  7, 42. 7. Catterall, W.A. et al. (2003) Pharmacol Rev  55, 575. 8. Catterall, W.A. et al. (2005) Pharmacol. Rev. 57, 397. 9. Yang, Y. et al. (2004) J. Med. Genet. 41, 171. 10. Cummins, T.R. et al. (2004) J. Neurosci. 24, 8232. 11. Dray, A. (2008) Br. J. Anaesth. 101, 48.

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$ 375.00
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$ 575.00
Cat# AG1034-025
(40 western blots)
Availability: 2-3 weeks
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