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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NaV1.3 Antibody   

NaV1.3 Antibody

Affinity purified polyclonal antibody

  • WB - NaV1.3 Antibody AG1036-025
    Western blot analysis of rat newborn brain membranes:
    1. Anti-Nav1.3 antibody (#AG1036), (1:200).
    2. Anti-Nav1.3 antibody, preincubated with the control peptide antigen.
  • IHC - NaV1.3 Antibody AG1036-025
    Expression of Nav1.3 in rat embryo DRG
    Immunohistochemical staining of rat embryo dorsal root ganglion (DRG) frozen sections using Anti-Nav1.3 antibody (#AG1036), (1:100). Nav1.3 is expressed in DRG embryonic cells (arrows). Calibration bar = 50 µm.
  • ICC - NaV1.3 Antibody AG1036-025
    Expression of Nav1.3 in rat DRG primary cells  Immunocytochemical staining of paraformaldehyde-fixed and permeabilized  rat dorsal root ganglia (DRG) primary culture. A. DRG cells were stained using Anti-Nav1.3 antibody (#AG1036), (1:200) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. B. Nuclear staining of cells using the cell-permeable dye Hoechst 33342. C. Merged image of panels A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08104
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 221387 Da
Homology Mouse - 12/14 amino acid residues identical.
Additional Information
Gene ID 497770
Other Names Sodium channel protein type 3 subunit alpha, Sodium channel protein brain III subunit alpha, Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subtype III, Voltage-gated sodium channel subunit alpha Nav13, Scn3a
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)HLEGNHRADGDRFP, corresponding to amino acid residues 511-524 rat Nav1.3 (Accession P08104).ֲ ֲ Intracellular, loop between domains I and II.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Application Details Western blot analysis (WB): - Mouse brain (see Verret, L. et al. (2012) in Product Citations). - Mouse brain membrane lysate (see Kim, D.Y. et al. (2011) in Product Citations).   Immunoprecipitation (IP): - CNahIII-12 cells expressing human NaV1.3 and β1 subunit. (see Meadows, L.S. et al. (2002) in Product Citations). Immunohistochemistry (IH): - Rat brain sections (1:250) (see Hargus, N.J. et al. (2013) in Product Citations). - Rat brain sections (1:200) (see Lindia, J.A. and Abbadie, C. (2003) in Product Citations). Immunocytochemistry (IC): - Mouse LVA myocytes (1:100) (see Ednie, A.R. et al. (2013) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 1 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 0.75 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.4-5  The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7)  and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7   Nav1.3 is highly expressed in embryonic sensory neurons and CNS, but its level dramatically decreases in adult rodents.8 Up-regulation of Nav1.3 channel expression was described in injured neurons and injured spinal cord.9-11


References 1. Wu, L. et al. (2002) NeuroReport 13, 2547. 2. Fang, X. et al. (2002) J. Neurosci. 22, 7425. 3. Fjell, J. et al. (2000) NeuroReport 11, 199. 4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 5. Lai, J. et al. (2003) Curr.Opin. Neurobiol 13, 291. 6. Isom, L.L. (2001) Neuroscientist  7, 42. 7. Catterall, W.A. et al. (2003) Pharmacol Rev  55, 575. 8. Lai, J. et al. (2004) Annu. Rev. Pharmacol. Toxicol. 44, 371. 9. Hains, B.C. et al. (2003) J. Neurosci. 23, 8881. 10. Cummins, T. R. et al. (2001) J. Neurosci. 21, 5952. 11. Shah, B. S. et al. (2001) J. Physiol. 534.3, 763.

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Cat# AG1036-025
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