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Caspr2 Antibody

Affinity purified polyclonal antibody

  • WB - Caspr2 Antibody AG1050-050
    Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1-2. Anti-Caspr2 antibody (#AG1050), (1:200).
    3-4. Anti-Caspr2 antibody, preincubated with the control peptide antigen.
  • IHC - Caspr2 Antibody AG1050-050
    Expression of Caspr2 in rat cerebellum Immunohistochemical staining of rat brain frozen sections using Anti-Caspr2 antibody (#AG1050), (1:200), (green). A. Caspr2 appears in pinceau structures (arrows) and diffusely in the molecular layer (MOL). Staining of the same section for parvalbumin (red) labels Purkinje cells and demonstrates the position of the pinceau under Purkinje cells. B. Pre-incubation of the antibody with the caspr2 peptide antigen blocks the staining, demonstrating specificity.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHC6
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 148167 Da
Homology Mouse, rat - identical
Additional Information
Gene ID 26047
Other Names Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2 (Accession Q9UHC6). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.4 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell–cell interactions in the nervous system1,2. Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell – cell adhesion complexes via binding to their postsynaptic partners the neuroligins2. Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains,  an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2. Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1. The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels Kv1.1, Kv1.2, and their cytoplasmic Kvß2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3. Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6. Abgent is pleased to offer a highly specific antibody directed against an epitope located at the intracellular C-terminal domain of human Caspr2. Anti-Caspr2 antibody (#AG1050) can be used in Western blot applications, and was designed to recognize Caspr2 from rat, mouse and human samples.


References 1. Poliak, S. et al. (1999) Neuron  24, 1037. 2. Craig A. M. and Kang Y. (2007) Curr. Opin Neurobiol. 17, 43. 3. Poliak, S. et al. (2003) J. Cell Biol. 162, 1149. 4. Strauss, K.A. et al. (2006) N. Engl. J. Med. 354, 1370. 5. Friedman, J.I. et al. (2008) Mol. Psychiatry. 13, 261. 6. Alarcon, M. et al. (2008) Am. J. Hum. Genet. 82, 150.

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$ 475.00
$ 575.00
Cat# AG1050-050
(40 western blots)
Availability: 2-3 weeks
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