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P2Y1 Receptor Antibody

Affinity purified rabbit polyclonal antibody

  • WB - P2Y1 Receptor Antibody AG1070-050
    Western blot analysis of rat brain membranes (1, 3) and human platelets lysate (2, 4): 1, 2. Anti-P2Y1 Receptor antibody (#AG1070), (1:200). 3, 4. Anti-P2Y1 Receptor antibody, preincubated with the control peptide antigen.
  • IHC - P2Y1 Receptor Antibody AG1070-050
    Expression of P2Y1 in rat thalamus Immunohistochemical staining of Fasciculi in rat thalamus using Anti-P2Y1 Receptor antibody (#AG1070). Specific staining is black. Cresyl violet is used as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49651
Other Accession P47900
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42322 Da
Homology Rat, human, bovine - identical; turkey, chicken - 16/17 amino acid residues identical; mouse - 15/17 amino acid residues identical.
Additional Information
Gene ID 25265
Other Names P2Y purinoceptor 1, P2Y1, ATP receptor, Purinergic receptor, P2ry1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)RALI YKDLD NSPLR RKS, corresponding to residues 242-258 of rat or human P2Y1. (Accession P49651, P47900). 3rd intracellular loop (i3) between TM5 and TM6 domains.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Application Details Western blot analysis (WB): - Mouse spinal cord astrocyte lysate (1:200) (see Suadicani, S.O. et al. (2003) in Product Citations). Immunoprecipitation (IP): - Rat cortical neuron lysate (4 μg) (see Siow, N.L. et al. (2010) in Product Citations). Immunohistochemistry (IH): - Human eye tissue (see Fries, J.E. et al. (2005) in Product Citations). Immunocytochemistry (IC): - Human fibroblasts (1:50) (see Pinheiro, A.R. et al. (2013) in Product Citations). - Rat primary hippocampal neurons (1:100) (see Filippov, A.K. et al. (2006) in Product Citations). Indirect flow cytometry (IFC): - Rat osteoclasts (6 μg/ml) (see Alvarenga, E.C. et al. (2010) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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The P2Y receptors belong to the G-protein coupled receptors superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among them, cardiac function, platelet aggregation and SMC proliferation.1 The mammalian P2Y family currently includes eight functional receptors; P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.2-4 P2Y1 receptor is abundantly expressed in a number of tissues. In platelets, P2Y1 receptor is co-expressed with P2Y12 receptor, responsible for the initial shape change, aggregation, and rise in intracellular Ca2+ upon activation in response to ADP.5


1. Wang, L. et al. (2002) J. Cardiovas. Pharmacol. 40, 841.
2. Queiroz, G. et al. (2003) J. Pharmacol. Exp. Ther. 307, 809.
3. Ralevic, V. and Burnstock, G. (1998) Pharmacol. Rev. 50, 413.
4. Abbracchio, M.P. et al. (2003) Trends. Pharmacol. Sci. 24, 52.
5. Jin, J. et al. (1998) J. Biol. Chem. 273, 2030.

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$ 475.00
$ 575.00
Cat# AG1070-050
(40 western blots)
Availability: 2-3 weeks
Bulk Size
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