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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   P2X5 Receptor Antibody   

P2X5 Receptor Antibody

Affinity purified polyclonal antibody

  • WB - P2X5 Receptor Antibody AG1073-050
    Western blot analysis of rat brain membranes: 1. Anti-P2X5 Receptor antibody (#AG1073), (1:200). 
    2. Anti-P2X5 Receptor antibody, preincubated with the control peptide antigen.
  • IHC - P2X5 Receptor Antibody AG1073-050
    Expression of P2X5 Receptor in rat spinal cord
    Immunohistochemical staining of rat spinal cord frozen section using Anti-P2X5 Receptor antibody (#AG1073), (1:100). P2X5 Receptor staining (red) is specific for neurons in the anterior horn of the spinal cord. Hoechst 33342  is used as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51578
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 51479 Da
Homology Mouse- 13/18 amino acid residues identical.
Additional Information
Gene ID 113995
Other Names P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2rx5
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)RENAIVNVKQSQILHPVKT, corresponding to amino acid residues 437-455 ofֲ rat P2X5 Receptor (Accessionֲ  P51578). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and by massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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The P2X5 receptor (P2X5R) belongs to the ligand-gated ion channel P2X family, which is activated by extracellular ATP.   To date, seven receptor subtypes named P2X1-P2X7 have been described.1,2,3   All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels.4-5 The P2X5R forms a heteromeric receptor with P2X1 receptor. The heteromeric receptor has distinct properties from the P2X1 or P2X5 homomeric receptors.4,6 The different P2X receptors show distinct expression patterns.   P2X1-6 have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly antigen presenting cells, and in microglia.   The P2X5 subunit was first cloned from rat heart, and was reported to be expressed in heart, brain, spinal cord and adrenal gland.    Recent papers suggested possible roles for P2X5 receptor in differentiation and apoptosis in keratinocytes and ageing rat prostate, respectively.7-10 We are pleased to offer a new antibody to our growing line of ligand-gated ion channel P2X antibodies, Anti-P2X5 Receptor antibody.


References 1. Prasad, M. et al. (2001) J. Physiol. 573, 667.  2. Florenzano, F. et al. (2002) Neuroscience 115, 425. 3. Ashcroft, F.M. et al. (2000) Ion Channels and Disease Ed.1. 4. Khakh, B.S. et al. (2001) Pharmacol. Rev. 53, 107.  5. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.  6. Torres, G.E. et al. (1998) Mol. Pharmacol. 54, 989.  7. Greig, A.V. et al. (2003) J. Invest. Dermatol. 121, 1145. 8. Greig, A.V. et al. (2003) J. Invest. Dermatol. 120, 1007. 9. Slater, M. et al. (2000) Histochem. J. 32, 571. 10. Afework, M. and Burnstock, G. (2000) Int. J. Devl. Neuroscience 18, 515.

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$ 367.00
$ 475.00
Cat# AG1073-050
Availability: 2-3 weeks
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