|Reactivity||Human, Mouse, Rat|
|Calculated MW||102258 Da|
|Homology||Human, rat - identical.|
|Other Names||Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv75, Kcnq5|
|Related products for control experiments||Control peptide antigen (supplied with the antibody free of charge).|
|Target/Specificity||Peptide (C)RGSQDFYPKWRESK, corresponding to amino acid residues 856-869 of mouse Kv7.5 (Accession Q9JK45). Intracellular, C-terminus.|
|Peptide Confirmation||Confirmed by mass-spectrography and amino acid analysis.|
|Format||Affinity purified antibody, lyophilized powder|
|Reconstitution||50 µl or 0.2 ml deionized water, depending on the sample size.|
|Antibody Concentration After Reconstitution||0.8 mg/ml.|
|Buffer After Reconstitution||Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.|
|Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Storage After Reconstitution||The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).|
|Control Antigen Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Control Antigen Reconstitution||100 µl DDW.|
|Control Antigen Storage After Reconstitution||-20ºC.|
|Preadsorption Control||1 µg peptide per 1 µg antibody.|
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Provided below are standard protocols that you may find useful for product applications.
KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KV7.1-KV7.5) of which KV7.2 to KV7.5 are expressed in the nervous system1-3. KV7.5 is also expressed in visceral smooth muscle4 and skeletal muscle5. These channels form subunits of the low threshold voltage gated K+ channel. KV7.2 and KV7.3 mostly form heteromers to form the M current. KV7.5 is known to contribute to this current1.
References 1. Brown, D.A. and Passmore, G.M. (2009) Br. J. Pharmacol. 156, 1185. 2. Jentsch, T.J. (2000) Nat. Rev. Neurosci. 1, 21. 3. Robbins, J. (2001) Pharmacol. Ther. 90, 1. 4. Jensen, H.S. et al. (2005) Brain Res. Mol. Brain Res. 139, 52. 5. Lerche, C. et al. (2000) J. Biol. Chem. 275, 22395.
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