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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KV6.1 (extracellular) Antibody   

KV6.1 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - KV6.1 (extracellular) Antibody AG1082-050
    Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes:
    1-2. Anti-KV6.1 (extracellular) antibody (#AG1082), (1:400).
    3-4. Anti-KV6.1 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - KV6.1 (extracellular) Antibody AG1082-050
    Expression of KV6.1 in rat cerebellum
    Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-KV6.1 (extracellular) antibody (#AG1082), (1:200). A. KV6.1 is detected in rat cerebellum (red). Staining is apparent in Purkinje neurons (arrow) and in the molecular layer (Mol). B. Cell nuclei in the same section are stained with DAPI (blue). C. Merge of the two images.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A2BDX4
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 58176 Da
Homology Rat - identical; human - 11/13 amino acid residues identical.
Additional Information
Gene ID 241794
Other Names Potassium voltage-gated channel subfamily G member 1, Voltage-gated potassium channel subunit Kv61, Kcng1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)RRKPSTGNSYLDK, corresponding to amino acid residues 325- 337 of mouse Kv6.1 (Accession A2BDX4). 2nd extracellular loop.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 2 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Resuspended antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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Voltage-gated K+ channels are transmembrane proteins consisting of four α-subunits arranged in a radially symmetric fashion around a central aqueous pore. Each α-subunit consists of six transmembrane segments (S1-S6) with cytoplasmic NH2- and COOH-termini.   In mammals, a large family of genes encodes α-subunits: KV1 (homologous to Drosophila Shaker), KV2 (Shab), KV3 (Shaw), KV4 (Shal), KV5, KV6, and KV91. The sparsely populated KV channel subfamilies KV5 and KV6 each contain one member, KV5.1 and KV6.12. KV6 channels are electrically silent and no functional role has been suggested for these channels3. A recent study found that KV6.1 forms functional channels specifically with KV2.13. It was also found that KV2.1 and KV6.1 mRNAs colocalize to the piriform cortex, hippocampus, dendate gyrus and olfactory tubercle in the brain4 and to SA node, atria and ventricle in the heart5. This suggests that KV6.1 may be physiologically important in generating an increased number of KV channel phenotypes even though it does not itself form functional homomultimeric channels3.  Another study found that KV6.1 regulates the kinetics of KV2.2 channels. KV2.1/6.1 coexpression results in channels with markedly slower inactivation during strong depolarization but faster inactivation at intermediate potentials1


References 1. Kramer J.W. et al. (1998) Am. J. Physiol. 274, C1501. 2. Chandy, K.G., et al. (1995) Ligand- and Voltage-Gated Ion Channels, R.A. North, Ed. 1.  3. Post, M.A. et al. (1996) FEBS Lett.  399, 177.  4. Drewe, J.A. et al. (1992) J. Neurosci. 12, 538.  5. Dixon, J.E. et al. (1994) Circ. Res. 75, 252.

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$ 367.00
$ 475.00
Cat# AG1082-050
Availability: 2-3 weeks
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