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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KV4.1 Antibody   

KV4.1 Antibody

Affinity purified polyclonal antibody

  • WB - KV4.1 Antibody AG1094-050
    Western blot analysis of rat brain lysate:
    1. Anti-KV4.1 antibody (#AG1094), (1:400).
    2. Anti- KV4.1 antibody, preincubated with the control peptide antigen.
  • WB - KV4.1 Antibody AG1094-050
    Western blot analysis of human neuroblastoma cell line SH-SY5Y (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4):
    1, 2. Anti-KV4.1 antibody (#AG1094), (1:400).
    3, 4. Anti-KV4.1 antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NSA2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 71330 Da
Homology Mouse, rat - 12/13 amino acid residues identical.
Additional Information
Gene ID 3750
Other Names Potassium voltage-gated channel subfamily D member 1, Voltage-gated potassium channel subunit Kv41, KCND1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)KRRAIRLANSTAS, corresponding to amino acid residues 538-550 of human Kv4.1 (Accession Q9NSA2 ). Intracellular, C-terminal domain.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Kv4.1 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: Kv4.2 and Kv4.3. Kv4.1 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of Kv4.1 and Kv4.2. The Kv4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of Kv4.1 and Kv4.2 subunits. The biophysical properties of the Kv4.1 subunit can be modified by its association with auxiliary b subunits such as KChIP1 that increase Kv4.1 current densities and accelerates both the inactivation and the recovery time. Kv4.1 is highly expressed in brain but is also expressed in peripheral tissues such as colon, heart and lung. The pharmacology of Kv4.1 has been less well studied than that of the other Kv4 members. Kv4.1 is sensitive to the classical K+ channel blockers, 4-aminopyridine and tetraethylammonium. Recently HmTx1 a peptide blocker derived from the venom of the African tarantula Heteroscodra maculata has been shown to be a potent inhibitor of Kv4.1. Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of human Kv4.1. The Anti-Kv4.1 antibody (#AG1094) can be used for western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize Kv4.1 from rat, human and mouse samples.


References 1. Pak, M.D. et al. (1991) Proc. Natl. Acad. Sci. 88, 4386. 2. Song, W.J. et al. (1998) J. Neurosci. 18, 3124. 3. Escoubas, P. et al. (2002) Mol. Pharmacol. 62, 48. 4. Birnbaum, S. et al. (2004) Physiol. Rev. 84, 803.

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$ 475.00
$ 575.00
Cat# AG1094-050
Availability: 2-3 weeks
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