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>   home   >   Products   >   Primary Antibodies   >   KV12.3 (Elk3) Antibody   

KV12.3 (Elk3) Antibody

Affinity purified polyclonal antibody

  • WB - KV12.3 (Elk3) Antibody AG1097-050
    Western blot analysis of rat brain (lanes 1 and 3) and cerebellum (lanes 2 and 4) lysates:
    1, 2. Anti-KV12.3 (Elk3) antibody (#AG1097), (1:200).
    3, 4. Anti-KV12.3 (Elk3) antibody, preincubated with the control peptide antigen.
  • IHC - KV12.3 (Elk3) Antibody AG1097-050
    Expression of Kv12.3 in rat testes
    Immunohistochemical staining of rat testes paraffin embedded section using Anti-Kv12.3 (Elk3) antibody (#AG1097), (1:100).
    Kv12.3 (pink staining) is expressed in the columnar epithelium of the epididymus. Hematoxilin is used as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9R1T9
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 111404 Da
Homology Human - identical.
Additional Information
Gene ID 114032
Other Names Potassium voltage-gated channel subfamily H member 4, Brain-specific eag-like channel 2, BEC2, Ether-a-go-go-like potassium channel 1, ELK channel 1, rElk1, Voltage-gated potassium channel subunit Kv123, Kcnh4, Elk1, Elk3
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CRLNQEISRLNQEVS, corresponding to amino acids 881-895 of rat Kv12.3 (Accession Q9R1T9). Intracellular, C-terminal part.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
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Kv12.3 (also known as elk3 and KCNH4) is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. These are the eag (Kv10) with two members, the eag-related channels (erg or Kv11) and the eag-like K+ channels (elk or Kv12) with three members each. As all members of the family, Kv12.3 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv12 subfamily members can form functional heteromultimers within the subfamily.1,2   Kv12.3 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as testis and lung.3   The physiological function of the Kv12.3 channel hasn’t been established, although a role in the modulation of overall excitability of neurons has been suggested.3     At the moment there isn’t much pharmacological data concerning the modulation of the Kv12.3 channel except for blocking of the channel by Ba2+.3   Abgent is pleased to offer a highly specific antibody directed against an epitope located at the intracellular C-terminal part of the rat Kv12.3. Anti-Kv12.3 (Elk3) antibody (#AG1097) can be used in Western blot and immunohistochemical applications, and recognizes Kv12.3 from rat and human samples.


References 1. Engeland, B. et al. (1998) J Physiol 513, 647. 2. Miyake, A. et al. (1999) J Biol Chem 274, 25018. 3. Gutman, G.A. et al. (2005) Pharmacol. Rev. 57, 473.

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$ 367.00
$ 475.00
Cat# AG1097-050
Availability: 2-3 weeks
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