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>   home   >   Products   >   Primary Antibodies   >   KV12.1 (Elk1) Antibody   

KV12.1 (Elk1) Antibody

Affinity purified polyclonal antibody

  • WB - KV12.1 (Elk1) Antibody AG1099-050
    Western blot analysis of rat cortex lysate:

    1. Anti-Kv12.1 (Elk1) antibody (#AG1099), (1:200).
    2. Anti-Kv12.1 (Elk1) antibody, preincubated with the control peptide antigen.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9QWS8
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 123231 Da
Homology Mouse -14/15 amino acid residues identical; human -13/15 amino acid residues identical.
Additional Information
Gene ID 246325
Other Names Potassium voltage-gated channel subfamily H member 8, Ether-a-go-go-like potassium channel 3, ELK channel 3, Voltage-gated potassium channel subunit Kv121, Kcnh8, Elk1, Elk3
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide EDKKEDRAKGRSRAG(C), corresponding to amino acid residues 143-157 of rat Kv12.1 (Accession Q9QWS8).ֲ ֲ Intracellular, N-terminal part.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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Kv12.1 is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. They are the eag (Kv10) with two members, the eag-related channels (erg or Kv11) and the eag-like K+ channels (elk or Kv12) with three members each. As all members of the family, Kv12.1 possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv12 subfamily members can form functional heteromultimers within the subfamily.   Kv12.1 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as testis, colon and lung.   The physiological function of the Kv12.1 channel hasn’t been established, although a role in the modulation of overall excitability of neurons has been suggested.     At the moment there isn’t much pharmacological data concerning the modulation of the Kv12.1 channel except for blocking of the channel by Ba2+.   We have now produced a new Anti-Kv12.1 antibody that is directed against a highly conserved epitope of the rat protein. The antibody will probably recognize also human and mouse samples.


References 1. Shi, W. et al. (1998) J. Physiol. 511, 675. 2.  Zou, A. et al. (2003) Am. J. Physiol. Cell. Physiol. 285, C1356.

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$ 367.00
$ 475.00
Cat# AG1099-050
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