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KV11.3 (erg3) Antibody

Affinity purified polyclonal antibody

  • WB - KV11.3 (erg3)  Antibody AG1100-050
    Western blot analysis of rat brain lysate:

    1. Anti- Kv11.3 (erg3) antibody (#AG1100), (1:300).
    2. Anti- Kv11.3 (erg3) antibody, preincubated with the control peptide antigen.

  • IHC - KV11.3 (erg3)  Antibody AG1100-050
    Expression of KV11.3 in rat cerebellum Immunohistochemical staining of rat cerebellum using Anti-Kv11.3 (erg3) antibody (#AG1100).  A. Kv11.3 channel appears in glial processes (red). B. Staining of astrocytic fibers with mouse anti glial fibrillary acidic protein (GFAP, green). C. Confocal merge of Kv11.3 channel and GFAP demonstrates colocalization in the molecular layer but separate localization of these proteins at the Purkinje cell layer.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O54852
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 134901 Da
Homology Human - identical; mouse - 15/16 amino acid residues identical.
Additional Information
Gene ID 170739
Other Names Potassium voltage-gated channel subfamily H member 7, Ether-a-go-go-related gene potassium channel 3, ERG-3, Eag-related protein 3, Ether-a-go-go-related protein 3, Voltage-gated potassium channel subunit Kv113, Kcnh7, Erg3
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CPEFLDLEKSKLKSKE, corresponding to amino acid residues 1108-1123 of rat Kv11.3 (Accession O54852).ֲ ֲ Intracellular, C-terminal part.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Kv11.3 (erg3) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels. The erg subfamily includes the closely related proteins Kv11.1 (erg1) and Kv11.2 (erg2) that possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv11 subfamily members can form functional heteromultimers within the subfamily.   The current of the Kv11.1 and Kv11.2 channels is that of a strong inward rectifier with slow activating kinetics. The Kv11.3 channel has different biophysical properties: it is a weak inward rectifier that is activated at negative potentials and has rapid activating kinetics.   Kv11.3 expression is believed to be concentrated mainly in the brain with the stronger expression detected in the cerebral cortex and hippocampus.   At the moment there is not much pharmacological information concerning Kv11.3 modulation, but the channel has been shown to be inhibited (as are all Kv11 subfamily members) by the anti-arrhythmic E-4031 as well as by the anti-psychotic drugs sertindole and pimozide.   We have now produced a new Anti-Kv11.3 antibody that is directed against a highly conserved epitope of the rat protein. The antibody will also react with human and mouse samples.


References 1. Shi. W.M. et al. (1997) J. Neurosci. 17, 9423. 2. Wimmers. S. et al. (2001) Pflugers Arch. 441, 450. 3. Papa, M. et al. (2003) J. Comp. Neurol. 466, 119.

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Cat# AG1100-050
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