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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KV11.1 (HERG) (extracellular) Antibody   

KV11.1 (HERG) (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - KV11.1 (HERG) (extracellular) Antibody AG1102-025
    Western blot analysis of  Kv11.1 transfected HEK-293 cells:
    1. Anti-Kv11.1 (HERG) (extracellular) antibody (#AG1102), (1:200).
    2. Anti-Kv11.1 (HERG) (extracellular) antibody, preincubated with the control peptide antigen.
  • IP - KV11.1 (HERG) (extracellular) Antibody AG1102-025
    Immunoprecipitation of Kv11.1 expressing HEK-293 cells:
    Cell lysate. Lysate + protein A beads + Anti-Kv11.1 (HERG) (extracellular) antibody  (#AG1102). Lysate + protein A beads + Anti-Kv11.1 (erg1) antibody (#APC-016). Lysate + protein A beads + Anti-hKv11.1 (HERG) antibody (#APC-062). Lysate + protein A beads + pre-immune rabbit serum. Red arrow indicates Kv11.1 while the black arrow shows the IgG heavy chain.
    Immunoblot was performed with Anti-Kv11.1 (HERG) (extracellular) antibody.
  • IHC - KV11.1 (HERG) (extracellular) Antibody AG1102-025
    Expression of Kv11.1 in rat heart  Immunohistochemical staining of  rat heart using Anti-Kv11.1 (HERG) (extracellular) antibody (#AG1102). A. Transversal section of the atrium wall; note that arterial smooth muscle fibers were not stained (green arrow). B. Longitudinal section  of the myocardium. C. Section showing myocardium and endocardium (red arrow). DAB product is brown and the counterstain is cresyl violet.
  • ICC - KV11.1 (HERG) (extracellular) Antibody AG1102-025
    Expression of Kv11.1 in HEK-293 transfected cells Immunocytochemical staining of live intact HEK-293 transfected cells.Cells were stained with Anti-Kv11.1 (HERG) (extracellular) antibody (#AG1102), (1:25) (left panel) or with Kv11.1 (HERG) (extracellular) antibody preincubated with the control peptide antigen (right panel), followed by goat anti-rabbit-AlexaFluor-555 secondary antibody (red). Nuclei of the living cells were stained with the cell permeable dye Hoechst 33342 (blue). Note that not all cells are stained, indicating that not all the Kv11.1 channels are expressed at the cell membrane at the moment of staining.
  • FC - KV11.1 (HERG) (extracellular) Antibody AG1102-025
    Indirect flow cytometry analysis of human chronic myelogenous leukemia (K562) cells: ___ Unstained cells + goat-anti-rabbit-FITC.
    Black Cells + Anti-KV11.1 (HERG) (extracellular) antibody
    (#AG1102) + goat-anti-rabbit-FITC.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12809
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 126655 Da
Homology Rat, mouse - 11/16 amino acid residues identical; dog, rabbit - 15/16 amino residues identical.
Additional Information
Gene ID 3757
Other Names Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv111, KCNH2, ERG, ERG1, HERG
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1 (HERG) (Accessionֲ Q12809ֲ ).ֲ ֲ Extracellular, between S1 and S2 domains.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 2 µg peptide per 1 µg antibody.
Research Areas
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The KV11.1 (HERG) channel is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels that includes the related proteins KV11.2 and KV11.3 (erg2 and erg3). KV11.1 possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini. The KV11.1 current is characterized by strong inward rectification with slow activation and very rapid inactivation kinetics. The channel is expressed in the brain and heart (where it underlies the IKr current) and has a central role in mediating repolarization of action potentials. Mutations in the KV11.1 channel cause inherited long QT syndrome (LQTS) or abnormalities in the repolarization of the heart that are associated with life-threatening arrhythmias and sudden death. All the identified KV11.1 mutations produce loss of function of the channel via several cellular mechanisms ranging from alterations of gating properties, alterations of channel permeability/selectivity and alterations in intracellular channel trafficking that decreases the number of channels that reach the cell membrane. Lately drug-induced forms of LQTS have been reported for a wide range of non-cardiac drugs including antihistamines, psychoactive agents and antimicrobials. All these drugs potently block the KV11.1 channel as an unintended side effect, prompting regulatory drug agencies to issue recommendations for the testing of new drugs for their potential KV11.1 blocking effect. In addition, KV11.1 expression was found to be upregulated in several tumor cell lines of different histogenesis suggesting that it confers the cells some advantage in cell proliferation. Indeed, in several studies it has been shown that inhibition of the KV11.1 current leads to a decrease in tumor cell proliferation. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of human Kv11.1. The Anti-Kv11.1 (HERG) (extracellular) antibody (#AG1102) can be used for western blot, immunoprecipitation, immunohistochemical, immunocytochemical and indirect flow cytometry applications. It has been designed to recognize Kv11.1from rat and human samples. This antibody is a unique and invaluable tool to researchers looking into mutations affecting Kv11.1 trafficking or testing Kv11.1 expression in patients with hematopoietic malignancies among many other potential uses.


References 1. Curran, M.E. et al. (1995) Cell 80, 795. 2. Sanguinetti, M.C. et al. (1995) Cell 81, 299. 3. Pardo, L.A. et al. (2004) Physiology 19, 285.

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Cat# AG1102-025
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