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>   home   >   Products   >   Primary Antibodies   >   KV10.1 (EAG-1) Antibody   

KV10.1 (EAG-1) Antibody

Affinity purified polyclonal antibody

  • WB - KV10.1 (EAG-1) Antibody AG1105-025
    Western blot analysis of rat brain lysate (lanes 1 and 3) and HEK-KV10.1 (lanes 2 and 4):
    1, 2. Anti- KV10.1 (EAG-1) antibody (#AG1105), (1:200).
    3, 4. Anti-KV10.1 (EAG-1) antibody, preincubated with the control antigen.
  • ICC - KV10.1 (EAG-1) Antibody AG1105-025
    Expression of Kv10.1 in human MDA-468 mammary gland adenocarcinoma cells.  Immunocytochemical staining of pA. Cells were stained with Anti- Kv10.1 (EAG-1) antibody (#AG1105), (1:200) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody (red). B. Nuclei were visualized with the cell-permeable dye Hoechst 33342 (blue). C. Merged image of panels A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63472
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 108291 Da
Homology Mouse- identical; human -14/16 amino acid residues identical.
Additional Information
Gene ID 65198
Other Names Potassium voltage-gated channel subfamily H member 1, Ether-a-go-go potassium channel 1, EAG channel 1, EAG1, r-eag, Voltage-gated potassium channel subunit Kv101, Kcnh1, Eag
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide GDPAKRKGWARFKDAC, corresponding to amino acid residues 802-817 of rat KV10.1 (Accession Q63472).ֲ ֲ Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS) pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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KV10.1 is a member of the Ether-a-go-go family of voltage-activated K+ channels. To date, the family includes 8 members: the closely related KV10.2 (EAG-2) protein, the KV12 (elk) subfamily (elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3). As with the other KV superfamily members, KV10.1 shows the characteristic 6 transmembrane domains with intracelullar N and C termini. The KV10 subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. Its expression is normally confined to the brain where its physiological function has not yet been clarified. Intriguingly, the KV10.1 channel has been implicated in malignant tumor development. It has been shown that KV10.1 was inappropriately expressed in several cancer cell lines. Moreover, one study showed that KV10.1 by itself had oncogenic potential, as a cell line transfected with the channel, induced aggressive and faster tumor growth in vivo as compared to a cell line transfected with an unrelated KV channel. Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of rat Kv10.1. The Anti-Kv10.1 (EAG-1) antibody (#AG1105) can be used for western blot , immunohistochemical and immunocytochemical applications. It has been designed to recognize Kv10.1 from rat, human and mouse samples. The antibody is specific for KV10.1 and it will not crossreact with KV10.2.


References 1.  Ludwig, J. et al. (1994) EMBO J. 13, 4451. 2. Bauer, C. K. et al. (2001) J. Membrane Biol. 182, 1. 3. Pardo, LA. et al. (1999) EMBO J. 18, 5540.

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Cat# AG1105-025
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