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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   K2P5.1 (TASK-2) Antibody   

K2P5.1 (TASK-2) Antibody

Affinity purified polyclonal antibody

  • WB - K2P5.1 (TASK-2) Antibody AG1132-050
    Western blot analysis of rat kidney membranes:
    1. Anti-K2P5.1 (TASK-2) antibody (#AG1132), (1:200).
    2. Anti-K2P5.1 (TASK-2) antibody, preincubated with the control peptide antigen.
  • IHC - K2P5.1 (TASK-2) Antibody AG1132-050
    Expression of K2P5.1 in rat pancreas Immunohistochemical staining of rat pancreas was visualized using Anti-K2P5.1 (TASK-2) antibody (#AG1132), (1:50).  Paraffin embedded sections of rat pancreas showing both endocrine (Islets of Langerhans) and exocrine areas.  Strong and highly specific staining is evident only in endocrine cells (arrow).  Universal Immuno-alkaline-phosphatase Polymer followed by New Fuchsin Substrate (Histofine, Nichirei Corp.) was used for the color reaction. Hematoxilin is used as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95279
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55130 Da
Homology Mouse - 14/17 amino acid residues identical.
Additional Information
Gene ID 8645
Other Names Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2, KCNK5, TASK2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)YEQLMNEYNKANSPKGT, amino acid residues 483-499 of human K2P5.1 (Accession number O95279).ֲ ֲ Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.3 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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K2P5.1 (also named TWIK-Related Acid Sensitive K+ channel 2, TASK-2 or KCNK5) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.   The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. The functional channel is believed to be a dimer.   K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.   As indicated by its name, K2P5.1 is sensitive to variations in external pH. K2P5.1 current is maximal at pH 8.8 but it is only 10% at pH 6.5.    The channel is expressed in several epithelial tissues including pancreas, lung, small intestine and specially kidney. In the kidney K2P5.1 has an important function in NaHCO3 absorption in the proximal tubule as knockout mice for K2P5.1 display metabolic acidosis and hypotension.


References 1. Reyes, R. et al. (1998) J. Biol. Chem. 273, 30863. 2. Lesage, F. and Lazdunski, M. (2000) Am. J. Physiol. Renal Physiol.  279, F793. 3. Warth, R. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 8215.

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$ 475.00
$ 575.00
Cat# AG1132-050
(40 western blots)
Availability: 2-3 weeks
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