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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   slobeta2 (KCNMB2) Antibody   

slobeta2 (KCNMB2) Antibody

Affinity purified polyclonal antibody

  • WB - slobeta2 (KCNMB2) Antibody AG1134-025
    Western blot analysis of rat kidney (lanes 1 and 3) and rat heart (lanes 2 and 4) membranes: 1, 2.  Anti-sloβ2 (KCNMB2) antibody (#AG1134), (1:200).
    3, 4.  Anti-sloβ2 (KCNMB2) antibody, preincubated with the control peptide antigen.
  • IHC - slobeta2 (KCNMB2) Antibody AG1134-025
    Expression of sloβ2 in rat hippocampus
    Immunohistochemical staining of rat hippocampus using Anti-sloβ2 (KCNMB2) (#AG1134). A. sloβ2 appears in the pyramidal layer (green). B. Staining of interneurons with mouse anti parvalbumin (PV, red). C. Confocal merge of sloβ2 and PV demonstrates presence of sloβ2 also in PV (GABA containing) cells (orange).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y691
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 27130 Da
Homology Rat, dog- identical; mouse - 18/19 amino acid residues identical.
Additional Information
Gene ID 10242
Other Names Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)RHDEKRNIYQKIRDHDLLD, corresponding to amino acid residues 14-32 of human slo־²2 (Accession Q9Y691).ֲ ֲ Intracellular, N-terminal part.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Application Details Western blot analysis (WB): - Mitochondria and mitoplast from human endothelial EA.hy926 cells (1:200) (see Bednarczyk, P. et al. (2013) in Product Citations).  
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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sloβ2 is a member the regulatory β subunit family that controls the activity of the large conductance Ca2+-activated K+ channel KCa1.1. This family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region and a distinct tissue distribution. sloβ2 expression is relatively broad and includes expression in brain, heart, kidney adrenal chromaffin cells and ovary.                         The KCa1.1 K+ channel can be activated by either an increase in intracellular Ca2+ concentration or by membrane depolarization. The regulatory β subunits increase the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and membrane voltage and they may also change the channel pharmacology.   The sloβ2 subunit is unique in that it is able to induce a rapid and complete inactivation of the KCa1.1 channel in a manner that closely resembles the ball-and-chain inactivation of the voltage-dependent K+ (Kv) channels. In other words, the inactivation is dependent on a sequence in the N-terminal part of the sloβ2 subunit that appears to block the mouth of the ion permeation pathway. The physiological significance of the sloβ2 subunit is not clear, but it appears to participate in the inactivation of the KCa1.1 channel in hippocampal CA1 neurons and adrenal chromaffin cells.


References 1. Wallner, M. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 4137. 2. Xia, X.M. et al. (1999) J. Neurosci. 19, 5255. 3. Orio, P. et al. (2002) News Physiol. Sci. 17, 156.

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Cat# AG1134-025
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