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>   home   >   Products   >   Primary Antibodies   >   KV4.2 Antibody   

KV4.2 Antibody

Affinity purified polyclonal antibody

  • WB - KV4.2 Antibody AG1141-025
    Western blot analysis of rat brain membranes:
    1. Anti-KV4.2 antibody (#AG1141), (1:200).
    2. Anti-KV4.2 antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63881
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 70549 Da
Homology Mouse, human - 15/16 amino acid residues identical.
Additional Information
Gene ID 65180
Other Names Potassium voltage-gated channel subfamily D member 2, RK5, Shal1, Voltage-gated potassium channel subunit Kv42, Kcnd2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)SNQLQSSEDEPAFVSK, corresponding to amino acid residues 454-469 of rat Kv4.2 (Accession Q63881). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
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Kv4.2 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: Kv4.1 and Kv4.3.1 Kv4.2 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of Kv4.1 and Kv4.3.   The Kv4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of Kv4.2 and Kv4.1 subunits.2   The biophysical properties of the Kv4.2 subunit can be modified by its association with auxiliary ß subunits such as the KChIP family that increase Kv4.2 current densities and accelerates both the inactivation and the recovery time.   Kv4.2 is also highly expressed in the heart where together with Kv4.3 underlie the fast inactivating and recovering cardiac transient outward current Ito.3   Several  toxins from spider venoms are potent blockers (affecting the channels in the nanomolar range) of Kv4.2 channels. Among these the most potent and selective are Stromatoxin-1 (#STS-350), (1.2nM), Phrixotoxin-1 (#P-710), (5nM), Phrixotoxin-2 (#P-700), (34nM) and Heteropodatoxin-2 (#STH-340), (100nM).4 Abgent  is pleased to offer a highly specific antibody directed against an epitope of rat Kv4.2. Anti-Kv4.2 antibody (#AG1141) can be used in western blot, immunoprecipitation, immunocytochemistry and immunohistochemistry applications. It has been designed to recognize KV4.2 from human, rat and mouse samples.


References 1. Roberds, S.L. and Tamkun, M.M. (1991) Proc Natl Acad Sci USA 88,1798. 2. Serodio, P. et al. (1994) J Neurophysiol 72,1516. 3. Guo, W. et al. (2002) Circ Res 90, 586. 4. Escoubas, P. et al. (2002) Mol. Pharmacol. 62, 48.

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1141-025
(40 western blots)
Availability: 2-3 weeks
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