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>   home   >   Products   >   Primary Antibodies   >   Kir6.2 Antibody   

Kir6.2 Antibody

Affinity purified polyclonal antibody

  • WB - Kir6.2 Antibody AG1143-025
    Western blot analysis of rat pancreas membranes: 
    1. Anti-Kir6.2 antibody (#AG1143), (1:200).   
    2. Anti-Kir6.2 antibody, preincubated with the control peptide antigen.
  • IHC - Kir6.2 Antibody AG1143-025
    Expression of Kir6.2 in rat pancreas Immunohistochemical staining of rat pancreas using Anti-Kir6.2 antibody (#AG1143). A. Strong granular staining in a number of cells within the Islets of Langerhans is readily detected (red). B. The negative control slide shows no staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P70673
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 43608 Da
Homology Mouse- identical; human - 12/14 amino acid residues identical.
Additional Information
Gene ID 83535
Other Names ATP-sensitive inward rectifier potassium channel 11, BIR, Inward rectifier K(+) channel Kir62, Potassium channel, inwardly rectifying subfamily J member 11, Kcnj11
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)SVAVAKAKPKFSIS,ֲ corresponding to amino acid residues 372-385 of rat Kir6.2ֲ ֲ (accession number P70673). Intracellular, C-terminal part.The antibody is specific for Kir6.2, it does not cross react withKir6.1.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Application Details Western blot analysis (WB): - Human placenta and pancreas lysate (see Lybaert, P. et al. (2013) in Product Citations). - Rat primary adrenomedullary chromafin cells (AMCs), (1:1000) (see Salman, S. et al. (2013) in Product Citations). Immunohistochemistry (IH): - Human placenta sections (see Lybaert, P. et al. (2013) in Product Citations). Immunocytochemistry (IC): - Mouse ciliary cells (1:100) (see Ohba, T. et al. (2013) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.6 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 2 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS) pH 7.4, 1% BSA, 0.025% NaN3.
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Kir6.2 is a member of the inward rectifier K+ channels (Kir channels), a large family of voltage-independent K+ channels largely involved in stabilization of the membrane resting potential and in K+ transport across membranes. Kir channels can be modulated by a variety of intracellular agents such as protons, GTP-binding proteins and adenine nucleotides.   The ATP-sensitive channel (KATP) is especially important since it couples cellular metabolism (intracellular ATP levels) with cell excitability. KATP channels have been described in pancreatic b-cells, neurons, heart, skeletal and smooth muscle.   The KATP channel is composed of a Kir6.2 or Kir6.1 subunit and a sulphonylurea receptor (SUR) subunit.   The pancreatic KATP channel for example, is composed of a complex of Kir6.2 and   SUR1 subunits, while the cardiac KATP channel is composed of Kir6.2 and SUR2A complexes.  Impaired b-cell KATP channel function due to mutations in either Kir6.2 or SUR1 subunits has been linked to the recessive autosomal disorder called persistent hyperinsulinemic hypoglycemia of infancy (PHHI). In addition, a Kir6.2 variant has recently been linked to an increased risk of developing type-2 diabetes.


References 1. Babenko, A.P. et al. (1998) Annu. Rev. Physiol. 60, 667. 2. Huopio, H. et al. (2002) Am. J. Physiol. 283, 207.

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Cat# AG1143-025
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