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KV3.4 Antibody

Affinity purified polyclonal antibody

  • WB - KV3.4 Antibody AG1144-025
    Western blot analysis of rat brain membranes:
    1.  Anti-Kv3.4 antibody (#AG1144), (1:200).
    2. Anti-Kv3.4 antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63734
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 68435 Da
Homology Human - Identical.
Additional Information
Gene ID 684516
Other Names Potassium voltage-gated channel subfamily C member 4, Raw3, Voltage-gated potassium channel subunit Kv34, Kcnc4
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide EAGDD ERELA LQRLG PHEG(C), corresponding to amino acid residues 177-195 of rat Kv3.4 (Accession Q63734). Intracellular, N-terminal.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.3 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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Kv3.4 is a member of the voltage-gated K+ channel superfamily. Together with the related proteins Kv3.1, Kv3.2 and Kv3.3 they constitute the Shaw type subfamily family.1   As with all Kv channels, Kv3.4 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functional Kv channel is a tetramer that can either be a homomer or a heteromer of Kv3 subunits.2   Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing.2   Kv3.4 expression is wide and the channel can be found in brain, skeletal muscle, prostate and pancreas among others.   Kv3.4 subunits have been implicated recently in the response mechanism to chronic hypoxia and the etiology of Alzheimer's and Parkinson's diseases. In addition, Kv3.4 was found to associate with the auxiliary subunit KCNE3 (MirP2) in skeletal muscle. A mutation in KCNE3 (R83H) has been associated with an inherited form of periodic paralysis (Thyrotoxic hypokalemic periodic paralysis) that is caused by the altered physiological function of the Kv3.4 channel.3 Toxins from sea anemone, BDS-I (#B-400), (47nM) and BDS-II (#B-450), (56nM), are potent blockers of KV3.4 channels.4


References 1. Schroter, K.H. et al. (1991) FEBS Lett. 278, 211. 2. Rettig, J. et al. (1992) EMBO J. 11, 2473. 3. Abbott, G.W. et al. (2001) Cell 104, 217. 4. Diochot, S. et al. (1998) J. Biol. Chem. 273, 6744.

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Cat# AG1144-025
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