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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Human p75NTR (intracellular) Antibody   

Human p75NTR (intracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Human p75NTR (intracellular) Antibody AG1177-050
    Western blot analysis of rat brain membranes:
    1. Anti-Human p75 NTR (intracellular) antibody (#AG1177), (1:200).
    2. Anti-Human p75 NTR (intracellular) antibody, preincubated with the control peptide antigen.
  • WB - Human p75NTR (intracellular) Antibody AG1177-050
    Western blot analysis of human melanoma cells A875:
    1. Anti-Human p75 NTR (intracellular) antibody (#AG1177), (1:200).
    2. Anti-Human p75 NTR (intracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Human p75NTR (intracellular) Antibody AG1177-050
    Expression of p75NTR in mouse hippocampus A. Mouse hippocampal sections (frozen) were stained with Anti-Human p75NTR-intracellular antibody (#AG1177) (1:200). p75NTR (green) appeared in a subset of astrocytes. B. Astrocytes were visualized with Anti-glial fibrillary acidic protein (GFAP) antibody (red). C. A merge of the two images demonstrates appearance of p75NTR mainly in stratum radiatum (SOR) and only in a few astrocytes in the alveus (AL).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08138
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 45183 Da
Homology Mouse, rat - identical.
Additional Information
Gene ID 4804
Other Names Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CKQNKQGANSRPVNQT corresponding to amino acid residues 278-293 of human p75NTR (SwissProt accession P08138).ֲ ֲ  Intracellular, juxtamembrane domain.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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The p75NTR receptor is a member of the TNF receptor superfamily.  p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain.   p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.    As its name implies, p75NTR binds all the neurotrophins (NGF, BDNF, NT-3 and NT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival.   On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth.   We have now developed a new antibody specific for the p75NTR, Anti-Human p75NTR (intracellular) (#AG1177). This antibody was raised against a highly conserved epitope located in the juxtamembrane domain of the human p75NTR intracellular region.  The antibody works equally well in mouse and rat samples.


References 1. Hempstead, B.L. (2002) Curr. Opin. Neurobiol. 12, 260. 2. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299. 3. Barker, P.A. (2004) Neuron 42, 529.

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$ 475.00
$ 575.00
Cat# AG1177-050
(40 western blots)
Availability: 2-3 weeks
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