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Neuroligin 1 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Neuroligin 1 (extracellular) Antibody AG1185-050
    Western blot analysis of mouse brain (lanes 1 and 3) and rat brain lysates (lanes 2 and 4): 1, 2. Anti-Neuroligin 1 (extracellular) antibody (#AG1185), (1:800).
    3, 4. Anti-Neuroligin 1 (extracellular) antibody preincubated with the control peptide antigen.
  • IHC - Neuroligin 1 (extracellular) Antibody AG1185-050
    Expression of Neuroligin 1 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti-Neuroligin 1 (extracellular) antibody (#AG1185) followed by anti-rabbit-AlexaFluor-594 secondary antibody. A. Neuroligin 1 labeling (red) appears in the cell bodies of the DRG neurons. B. Nuclear staining using DAPI as the counter stain (blue). C. Merged image of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q62765
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 94294 Da
Homology Mouse-identical; human - 13/14 amino acid residues identical.
Additional Information
Gene ID 116647
Other Names Neuroligin-1, Neuroligin I, Nlgn1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)KVPSTDITLRPTRK, corresponding to amino acid residues 648-661 of rat Neuroligin 1 (Accession Q62765). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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The NLGN1 gene encodes a member of a family of neuronal cell surface proteins. Neuroligins act as ligands for β-Neurexins, cell adhesion proteins located presynaptically. Neuroligin and β-neurexin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neuroligin 1 may be involved in the formation and remodeling of central nervous system synapses1.   Proteins of this family may also mediate signaling by recruiting and stabilizing key synaptic components. This is done by interacting with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures1.   Mutations in the Neuroligin genes are implicated in autism and other cognitive disorders2.   Neuroligins have been found to play a role in angiogenesis, specifically in human pheripheral tissues3.   Neuroligins bind with the help of Ca2+ to the α-neurexin LNS (laminin, neurexin and sex hormone-binding globulin-like folding units) domains and to the β-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code4. This binding results in a heterotetramer made up of a Neuroligin-1 dimer and two Neurexin-1 β monomers5.


References 1. Scheiffele, P. et al. (2000) Cell 101, 657. 2. Sudhof, T.C. et al. (2008) Nature 455, 903-911. 3. Bottos, A. et al. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 20782. 4. Fabrichny, I.P. et al. (2007) Neuron 56, 979. 5. Arac, D. et al. (2007) Neuron 56, 992.

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$ 475.00
$ 575.00
Cat# AG1185-050
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