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Neuropeptide Y2 Receptor Antibody

Affinity purified polyclonal antibody

  • WB - Neuropeptide Y2 Receptor Antibody AG1188-050
    Western blot analysis of rat hippocampus and rat whole brain lysates: 1, 2. Anti-Neuropeptide Y2 Receptor antibody (#AG1188), (1:200).
    3, 4. Anti-Neuropeptide Y2 Receptor antibody, preincubated with the control peptide antigen.
  • IHC - Neuropeptide Y2 Receptor Antibody AG1188-050
    Expression of Neuropeptide YReceptor in rat cerebellum Immunohistochemical staining of frozen section of rat cerebellum using Anti-Neuropeptide YReceptor antibody (#AG1188), (1:100). Neuropeptide YReceptor (red) is detected in Purkinje cells. B. Nuclei were stained using DAPI as the counterstain. C. Merged image of A. and B.
  • ICC - Neuropeptide Y2 Receptor Antibody AG1188-050
    Expression of NPY2R in rat dorsal root ganglion cells Immunocytochemical staining of rat dorsal root ganglion (DRG) neurons. A, D. A paraformaldehyde-fixed and permeabilized DRG primary culture was stained with Anti-Neuropeptide Y2 Receptor antibody (#AG1188), (1:100) followed by Alexa-555-conjugated goat anti-rabbit secondary antibody. B, E. Nuclear fluorescence staining of cells using the membrane-permeable DNA dye Hoechst 33342. C. Merged images of panels A and B. F. Merged images of panels D and E.
    A-C: x20
    E-F: x100
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P97295
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42628 Da
Homology Rat - identical; human - 18/19 amino acid residues identical.
Additional Information
Gene ID 18167
Other Names Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, Npy2r
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CEQRLDAIHSEVSMTFKAK, corresponding to amino acid residues 346-364 of mouse NPY2R (Accession P97295). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 1 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2   NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2   The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.   Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2   NPY2R is primarily expressed in neurons as a presynaptic receptor. It is also strongly expressed in epithelia of the visceral tissues, including colon and kidney.4 NPY2R is involved in inhibition of neurotransmitter release mediated by NPY.Release of glutamate, the principal neuroexcitatory transmitter, is inhibited via the NPY2R receptor.6 Involvement of NPY2R in feeding behavior was also reported. PYY(3–36), an NPY2R agonist, acts to inhibit feeding via NPY2R.7


References 1. Stanic, D. et al. (2006) J. Comp. Neurol. 499, 357. 2. Körner, M. et al. (2004) Clin. Cancer Res. 10, 8426 3. Sun, L. and Miller, R.J. (1999) J. Neurophysiol. 81, 1391. 4. Bournat, J.C. and Allen, J.M. (2001) Brain Res. Mol. Brain Res. 90, 149. 5. Wheway, J. et al. (2005) J. Exp. Med. 202, 1527. 6. Silva, A.P. et al. (2006) FASEB J. 21, 671. 7. Batterham, R.L. et al. (2003) N. Engl. J. Med. 349, 941.

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$ 475.00
$ 575.00
Cat# AG1188-050
(40 western blots)
Availability: 2-3 weeks
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